PRAGUE MEDICAL REPORT, Vol 126 No 3 (2025), 151–154
Glucocorticoid Remediable Aldosteronism in a Family with a Strong History of Cerebral Aneurysms and Hypertension
Jan Zeman
, Crystal Kamilaris
DOI: https://doi.org/10.14712/23362936.2025.23
zveřejněno: 18. 09. 2025
Abstract
Glucocorticoid remediable aldosteronism (GRA) also known as familial hyperaldosteronism type 1 (FH1) is a rare genetic form of primary aldosteronism characterized by aldosterone overproduction regulated by adrenocorticotropic hormone (ACTH). We present the case of a 54-year-old woman with severe hypertension and hypokalemia. Genetic testing confirmed GRA by identifying a chimeric gene involving CYP11B1 and CYP11B2. This case highlights the importance of considering GRA in patients with resistant hypertension and a family history of cerebral aneurysms. Management involved glucocorticoid therapy and mineralocorticoid receptor antagonists, leading to significant improvement in blood pressure control.
klíčová slova: Glucocorticoid remediable aldosteronism; Familial hyperaldosteronism type 1; Primary aldosteronism; Hypertension; Cerebral aneurysm; Genetic testing; Mineralocorticoid receptor antagonist
Glucocorticoid Remediable Aldosteronism in a Family with a Strong History of Cerebral Aneurysms and Hypertension is licensed under a Creative Commons Attribution 4.0 International License.
210 x 297 mm
vychází: 4 x ročně
cena tištěného čísla: 450 Kč
ISSN: 1214-6994
E-ISSN: 2336-2936
