PRAGUE MEDICAL REPORT, Vol 125 No 3 (2024), 195–219
Cocaine-induced Movement Disorder: A Literature Review
Vishnu Vardhan Byroju, Jamir Pitton Rissardo, Ícaro Durante, Ana Letícia Fornari Caprara
DOI: https://doi.org/10.14712/23362936.2024.19
zveřejněno: 22. 08. 2024
Abstract
This study aims to describe movement disorders secondary to cocaine use. To our knowledge, while these presentations have been previously reported in the literature, a comprehensive review has not been published yet. We searched six databases from 1986 to 2022 without language restriction. Case reports, case series, and literature reviews have been analysed to find associations between cocaine use and movement disorders. The present study encompasses epidemiology, clinical manifestations, pathophysiology, and diagnostic challenges of abnormal movements associated with cocaine use. This review highlights the importance of proper initial evaluation and investigation taking into account the broad spectrum of differential diagnoses and exclusion of primary movement disorders. The role of the dopaminergic system in movement disorders is reviewed. Cocaine use is associated with movement disorders such as dystonia, parkinsonism, akathisia, and tics. The complex interaction of multiple factors, including other neurological conditions, such as Tourette syndrome, and additional substances of abuse is discussed. The presentation of these manifestations is often heterogeneous and does not follow a specific pattern. In this way, future research is needed to improve our understanding of the pathophysiological mechanisms and develop novel drug targets for these disorders. Increased awareness among the general public and policymakers could translate into reduced stigma and improved care.
klíčová slova: Cocaine; Tropane alkaloid; Psychostimulant; Drug abuse; Drug-induced; Movement disorder
Cocaine-induced Movement Disorder: A Literature Review is licensed under a Creative Commons Attribution 4.0 International License.
167 x 240 mm
vychází: 4 x ročně
cena tištěného čísla: 450 Kč
ISSN: 1214-6994
E-ISSN: 2336-2936