PRAGUE MEDICAL REPORT, Vol 120 No 2 (2019), 103–106
Kinetics of Myristic Acid Following Accidentally Induced Septic Response
Roman Zazula, Miroslav Průcha, František Pehal, Kseniya Dryahina, Michal Moravec, Martin Müller, Tomáš Nejtek
DOI: https://doi.org/10.14712/23362936.2019.15
zveřejněno: 07. 10. 2019
Abstract
Myristic acid was identified as a metabolite with the highest diagnostic sensitivity and specificity in the metabolome of patients with bacteraemia. Subsequently, its significant decrease was observed in patients in septic shock not responding to treatment. In our study we have captured myristic acid serum level kinetics in 96 hours following accidental intravenous self-administration of eubiotic Hylak forte causing infection-like systemic inflammatory response syndrome (SIRS). To our knowledge, this is the first time the kinetics of myristic acid levels is presented in a septic patient. Myristic acid was evaluated in comparison with other inflammatory biomarkers and with its level in a control group of healthy subjects. Myristic acid levels during septic response were significantly elevated in comparison with the control group. The peak level was recorded almost immediately after the insult with a gradual decrease within 96 hours. Myristic acid appears to be a promising biomarker in sepsis diagnostics, further research by our group into this topic is ongoing.
klíčová slova: Biomarkers; Sepsis; Myristic acid; Kinetics
Kinetics of Myristic Acid Following Accidentally Induced Septic Response is licensed under a Creative Commons Attribution 4.0 International License.
167 x 240 mm
vychází: 4 x ročně
cena tištěného čísla: 450 Kč
ISSN: 1214-6994
E-ISSN: 2336-2936