PRAGUE MEDICAL REPORT, Vol 118 No 2 (2017), 105–109
Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction
Martin Šíma, Jan Hartinger, Jan Rulíšek, Robert Šachl, Ondřej Slanař
DOI: https://doi.org/10.14712/23362936.2017.11
zveřejněno: 19. 09. 2017
Abstract
We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration with meropenem. If carbapenems need to be administered to valproic acid treated patient, other anticonvulsant addition seems to be the appropriate as most probably the valproic acid dose escalation would not be sufficient to achieve therapeutic serum concentration.
klíčová slova: Valproic acid; Meropenem; Drug interaction; Therapeutic drug monitoring
Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction is licensed under a Creative Commons Attribution 4.0 International License.
167 x 240 mm
vychází: 4 x ročně
cena tištěného čísla: 450 Kč
ISSN: 1214-6994
E-ISSN: 2336-2936
