PRAGUE MEDICAL REPORT, Vol 118 No 2 (2017), 95–99
IgG4-related Disease – A Patient with Multiple Organ Involvement
Miroslav Průcha, Lenka Sedláčková
DOI: https://doi.org/10.14712/23362936.2017.9
zveřejněno: 19. 09. 2017
Abstract
IgG4-related diseases represent a heterogeneous group of conditions characterised by elevated serum IgG4 levels and fibrotic or sclerosing changes in the affected organs or systems accompanied by IgG4-positive plasma cells. A disease associated with IgG4 may affect virtually any organ – salivary glands, periorbital tissue, kidneys, lungs, meninges, aorta, prostate, pericardium or skin. Histopathological findings are uniform, characterised by a major lymphoplasmocytic infiltrate and the presence of IgG4-producing plasma cells, irrespective of the affected site. It can be difficult to establish a correct diagnosis due to the lack of clinical symptoms. Treatment with immunosuppressive drugs provides good results and requires interdisciplinary cooperation.
klíčová slova: IgG4; Fibrosis; Sclerosis; Immunosuppressive therapy
IgG4-related Disease – A Patient with Multiple Organ Involvement is licensed under a Creative Commons Attribution 4.0 International License.
167 x 240 mm
vychází: 4 x ročně
cena tištěného čísla: 450 Kč
ISSN: 1214-6994
E-ISSN: 2336-2936