ACTA MEDICA, Vol 64 No 3 (2021), 187–192
Oral Ibandronate Therapy in Three Patients with Osteogenesis Imperfecta
Štěpán Kutílek, Ivana Plášilová, Sylva Skálová, Milan Bayer, Erika Ondrušová
zveřejněno: 11. 11. 2021
Introduction: Treatment with orally administered ibandronate is an effective way to increase bone mineral density (BMD) and reduce fracture rate in post-menopausal women and in men with osteoporosis. There are only very few reports concerning ibandronate therapy in children and adolescents, and in patients with osteogenesis imperfecta (OI), as bisphosphonates are not registered for therapeutic use in pediatrics. Case Report: We present three patients with OI, where once-monthly oral ibandronate increased spinal BMD after two and four years, respectively, of therapy without any occurrence of new fractures and no adverse reactions. Somatic growth was not affected by the ibandronate treatment. Conclusion: Once-monthly oral ibandronate increased BMD and most probably improved bone quality in young patients with OI.
Klíčová slova: ibandronate; osteogenesis imperfecta; bone mineral density
Oral Ibandronate Therapy in Three Patients with Osteogenesis Imperfecta is licensed under a Creative Commons Attribution 4.0 International License.