PLZEŇSKÝ LÉKAŘSKÝ SBORNÍK
A multi-disciplinary medical journal publishing scientific works from theoretical and clinical fields with English summaries as well as works by foreign contributors in English. The chapter "Faculty Life" offers personal messages, reports on the faculty's activities in the past year and presents a complete bibliography of the medical faculty's departments and clinics in the year. The journal has been published since 1956.
Journal homepage
Editorial board
Contact: miluse.volterova@lfp.cuni.cz
Distribution: Ilona.Baxova@lfp.cuni.cz
Journal homepage
Editorial board
Contact: miluse.volterova@lfp.cuni.cz
Distribution: Ilona.Baxova@lfp.cuni.cz
PLZEŇSKÝ LÉKAŘSKÝ SBORNÍK, Vol 2014 No 80 (2015), 27–30
Brain metabolism and electrogenesis in phenylketonuria
P. Sobotka
published online: 20. 04. 2015
abstract
Experimental phenylketonuria in young rats leads besides hyperphenylalaninemia to changes of brain aminoacids. Elevation of glycine approaches values characteristic for cogent syndrome of nonketotic hyperglycinemia. Local application of phenylalanine and its metabolites to the brain cortex is epileptogenic. Metabolismus a elektrogeneze mozku u fenylketonurie Experimentální fenylketonurie vyvolaná u mláďat potkanů vede kromě hyperfeylalaninemie ke změně spektra aminokyselin mozku. Zvýšení glycinu je obdobné syndromu neketotické hyperglycinemie mozku. Lokální aplikace fenylalaninu a jeho metabolitů na mozkovou kůru má epileptogenní účinek.
