Primary Mucinous Bladder Adenocarcinoma

Mucinous adenocarcinoma, a rare subtype of primary bladder adenocarcinoma, accounts for approximately 20% of primary bladder adenocarcinomas and should be distinguished carefully from secondary adenocarcinomas of gastrointestinal origin. Herein, we report an unusual case of primary mucinous adenocarcinoma arising from a villous adenoma in a 52-year-old male presenting with urinary difficulties and recurrent bladder tumours. The patient had a significant medical history including right nephrectomy and left ureterolithotomy. Radiological and pathological evaluations revealed invasive mucinous adenocarcinoma. Surgical management included radical cystectomy, left nephroureterectomy, right ureterectomy, segmental rectal resection, and bilateral pelvic lymphadenectomy. This case emphasizes the complexity of diagnosis and management, highlighting the importance of distinguishing primary bladder mucinous adenocarcinoma from secondary gastrointestinal malignancies.