PRAGUE MEDICAL REPORT
PRAGUE MEDICAL REPORT
Prague Medical Report is an English quarterly published multidisciplinary biomedical journal. Prague Medical Report was founded as Sborník lékařský in May 1885. The journal presents public primary scientific publications, short communications, casuistry, and reviews. It contains articles based on important specialised lectures and symposia.

PRAGUE MEDICAL REPORT, Vol 119 No 1 (2018), 9–29

Sepsis Diagnostics in the Era of “Omics” Technologies

Miroslav Průcha, Roman Zazula, Stefan Russwurm

DOI: https://doi.org/10.14712/23362936.2018.2
published online: 18. 04. 2018

abstract

Sepsis is a multifactorial clinical syndrome with an extremely dynamic clinical course and with high diverse clinical phenotype. Early diagnosis is crucial for the final clinical outcome. Previous studies have not identified a biomarker for the diagnosis of sepsis which would have sufficient sensitivity and specificity. Identification of the infectious agents or the use of molecular biology, next gene sequencing, has not brought significant benefit for the patient in terms of early diagnosis. Therefore, we are currently searching for biomarkers, through “omics” technologies with sufficient diagnostic specificity and sensitivity, able to predict the clinical course of the disease and the patient response to therapy. Current progress in the use of systems biology technologies brings us hope that by using big data from clinical trials such biomarkers will be found.

keywords: Sepsis; Genomics; Transcriptomics; Proteinomics; Metabolomics; Pharmacogenomics; Diagnostics

Creative Commons License
Sepsis Diagnostics in the Era of “Omics” Technologies is licensed under a Creative Commons Attribution 4.0 International License.

167 x 240 mm
periodicity: 4 x per year
print price: 450 czk
ISSN: 1214-6994
E-ISSN: 2336-2936

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