PRAGUE MEDICAL REPORT
PRAGUE MEDICAL REPORT
Prague Medical Report is an English quarterly published multidisciplinary biomedical journal. Prague Medical Report was founded as Sborník lékařský in May 1885. The journal presents public primary scientific publications, short communications, casuistry, and reviews. It contains articles based on important specialised lectures and symposia.

PRAGUE MEDICAL REPORT, Vol 118 No 2 (2017), 105–109

Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction

Martin Šíma, Jan Hartinger, Jan Rulíšek, Robert Šachl, Ondřej Slanař

DOI: https://doi.org/10.14712/23362936.2017.11
published online: 19. 09. 2017

abstract

We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration with meropenem. If carbapenems need to be administered to valproic acid treated patient, other anticonvulsant addition seems to be the appropriate as most probably the valproic acid dose escalation would not be sufficient to achieve therapeutic serum concentration.

keywords: Valproic acid; Meropenem; Drug interaction; Therapeutic drug monitoring

Creative Commons License
Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction is licensed under a Creative Commons Attribution 4.0 International License.

167 x 240 mm
periodicity: 4 x per year
print price: 450 czk
ISSN: 1214-6994
E-ISSN: 2336-2936

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