Brain cortex temperature and heart rate in newborn rats after influencing endogenous nitric oxide synthesis

Brain cortex temperature and heart rate in newborn rats after influencing endogenous nitric oxide synthesis Our results show that after administration of substrate for NOS, L-arginine, only minute changes of brain relative to body temperature and, immediately after injection, only small (nevertheless significant) differences of heart rate between animals given L-arginine and those applied NOS blocker, nitro-L-arginine, appear. This is probably due to a reflex response in which the carotid bodies might play a decisive role, as shown by some findings (12), rather to a direct effect on brain tissue. Teplota kůry mozku a srdeční frekvence u novorozených laboratorních potkanů po ovlivnění syntézy oxidu dusnatého Possible role of gaseous messenger and/or neuromodulator, nitric oxide (NO), in regulation of brain cortical and body temperature of laboratory rat pups was evaluated. Measurement of temperature (and heart rate) after intervention in NO metabolism confirmed its effects which revealed a complex consequences in various tissues (especially in the vascular endothelium and neurons).