ACTA MEDICA, Vol 65 No 3 (2022), 89–98
The Choroid after Half-Dose Photodynamic Therapy in Chronic Central Serous Chorioretinopathy
Evita Evangelia Christou, Andreas Katsanos, Ilias Georgalas, Vassilios Kozobolis, Christos Kalogeropoulos, Maria Stefaniotou
DOI: https://doi.org/10.14712/18059694.2022.24
published online: 02. 02. 2023
abstract
Purpose: To characterize choroidal structure and vasculature after half-dose verteporfin photodynamic therapy (hd-vPDT) in eyes with chronic central serous chorioretinopathy using Enhanced Depth Imaging Optical Coherence Tomography (EDI OCT) and Optical Coherence Tomography Angiography (OCT-A). Methods: This prospective case-control study included 10 eyes. Choroid was examined before and at 1 month following hd-vPDT. We measured choroidal thickness (CT) at subfoveal area and at 750 μm nasal and temporal of fovea and thickness of Haller and choriocapillaris/Sattler layers. Whole (WA), luminal (LA) and interstitial area (IA) at EDI-OCT, and perfusion density at OCT-A were analyzed. The unaffected fellow eyes were used for comparisons. Results: Mean CT at subfoveal area and at 750 μm nasal and temporal of fovea, values of Haller and choriocapillaris/Sattler layers and those of WA, LA and IA were reduced, while PD increased at 1 month after hd-vPDT (all p < 0.001). There was a significant (p < 0.05) negative correlation (ρ = −0.658) between PD and post-treatment logMARVA. None of analyzed parameters reached values of unaffected fellow eye. Conclusion: Following hd-vPDT, choroidal thickness with both luminal and interstitial components markedly decreased, while perfusion of choriocapillaris improved.
keywords: chronic central serous chorioretinopathy; half-dose photodynamic therapy; enhanced depth imaging; optical coherence tomography; optical coherence tomography angiography; PDT
The Choroid after Half-Dose Photodynamic Therapy in Chronic Central Serous Chorioretinopathy is licensed under a Creative Commons Attribution 4.0 International License.
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ISSN: 1211-4286
E-ISSN: 1805-9694