ACTA MEDICA, Vol 59 No 3 (2016), 91–96
Effect of Riboflavin/UVA Collagen Cross-linking on Central Cornea, Limbus and Intraocular Pressure. Experimental Study in Rabbit Eyes
Vassilios Kozobolis, Maria Gkika, Haris Sideroudi, Efthymia Tsaragli, Stylliani Lydataki, Irini Naoumidi, Alexandra Giatromanolaki, Dimitrios Mikropoulos, Miguel Teus, Georgios Labiris
DOI: https://doi.org/10.14712/18059694.2016.96
published online: 24. 10. 2016
abstract
The Purpose of present study was to investigate the effect of riboflavin/ultraviolet-A-induced collagen cross-linking (CXL) on central cornea, limbus and intraocular pressure (IOP). This was an animal experimental study. The right corneas of 10 rabbits were ultraviolet-A irradiated (3 mW/cm2 for 30 minutes) after de-epithelialization and instillation of 0.1% riboflavin / 20% Dextran drops. Left corneas served as controls. Samples were examined histologically one month postoperatively. Before and after treatment, IOP measurements were recorded bilaterally. At central cornea of eyes underwent CXL keratocyte repopulation, normal arrangement of collagen fibres and a statistically significant change in fibres diameter were detected, compared to controls. At limbus area, there were not any significant histological differences after CXL. There was no statistically significant difference between pre- and postoperative IOP in all eyes.
keywords: Corneal Crosslinking; Intraocular pressure; Limbus; Cornea
Effect of Riboflavin/UVA Collagen Cross-linking on Central Cornea, Limbus and Intraocular Pressure. Experimental Study in Rabbit Eyes is licensed under a Creative Commons Attribution 4.0 International License.
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ISSN: 1211-4286
E-ISSN: 1805-9694
